Chimeric lysin

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August undefined, 2024

WebJul 20, 2024 · Dental caries is a common disease caused by oral bacteria. Streptococcus mutans and Streptococcus sobrinus are the primary cariogenic microbes that often survive as biofilms on teeth. In this study, we evaluated the activity of ClyR, a well-known chimeric lysin with extended streptococcal host range, against common Gram-positive oral … WebMay 15, 2024 · Activation of the immune system using antigen targeting to the dendritic cell receptor DEC205 presents great potential in the field of vaccination. The objective of this work was to evaluate the immunogenicity and protectiveness of a recombinant mouse x pig chimeric antibody fused with peptides of structural and nonstructural proteins of porcine …

Evaluation of a Recombinant Mouse X Pig Chimeric Anti-Porcine …

WebFeb 1, 2024 · Chimeric ClyV lysin (obtained by fusion of the enzymatically active domain from PlyGBS lysin and the cell wall binding domain from PlyV12 lysin) presented improved bactericidal activity in vitro ... WebSep 15, 2014 · Developing chimeric lysins with a wide lytic spectrum would be important for treating some infections caused by multiple pathogenic bacteria. In the present work, a novel chimeric lysin (Ply187N-V12C) … derric harsh

Construction of a chimeric lysin Ply187N‐V12C with …

WebNov 28, 2024 · Scientific Reports - Csl2, a novel chimeric bacteriophage lysin to fight infections caused by Streptococcus suis, an emerging zoonotic pathogen Skip to main … WebApr 19, 2024 · In this study, a novel chimeric lysin, ClyC, was constructed by fusing the CD from the Ply187 lysin with the CBD from the LysSA97 lysin. The CD of Ply187 (1–157aa, Ply187N) was chosen because it has been shown to have much higher activity compared to its parental full length S. aureus phage Ply187 [ 25 ]. WebMar 1, 2015 · The chimera Cpl-711 substantially improved the killing activity of the parental phage lysozymes, Cpl-1 and Cpl-7S, against pneumococcal bacteria, including … c-hr xle suv reviews

Construction of a chimeric lysin Ply187N â …

ClyJ Is a Novel Pneumococcal Chimeric Lysin with a …

WebMar 1, 2015 · The increased lethal action of Cpl-711 has been validated in a mouse model of bacteraemia, confirming that this new chimeric lysin is the most potent enzyme against pneumococci described so far. Materials and methods Ethics statement. All experiments were performed under strict adherence to the NIH guidelines for the ethical treatment of … WebMar 27, 2024 · In addition, the chimeric lysin, ClyJ, was constructed by fusing GPB coding sequence to the C terminus of the CHAP domain of PlyCA (amino acids 314 to 465) using sequence-specific primers (Table S4). The pneumococcal Cpl-1 lysin coding sequence was chemically synthesized by GenScript (Nanjing, China) and cloned into a pET28b(+) … chrx microwave recioeWebNov 4, 2013 · The chimeric lysin ClyH was constructed by fusing the N-terminal 157 amino acids of Ply187 (Pc) with the C-terminal 97 amino acids of phiNM3 lysin. To do this, the DNA fragment encoding the chimeric lysin was chemically synthesized by Songon Biotech (Shanghai, China). derriaghy church

"WebMay 25, 2024 · A newly evolved chimeric lysin motif receptor-like kinase in Medicago truncatula spp. tricycla R108 extends its Rhizobia symbiotic partnership. ... Using genomics and reverse genetics, we identified a newly evolved, chimeric LysM receptor-like kinase gene in R108, LYK2bis, ... " - Chimeric lysin

Chimeric lysin

WebJun 5, 2024 · A novel chimeric phage lysin with high in vitro and in vivo bactericidal activity against Streptococcus pneumoniae. J. Antimicrob. Chemother. 70, 1763–1773. 10.1093/jac/dkv038 [Google Scholar] Domenech M., García E., Moscoso M. (2011). WebNov 16, 2024 · Cationic peptide chimeric lysins, Lysqdvp001-5aa, Lysqdvp001-10aa and Lysqdvp001-15aa, were designed based on lysin Lysqdvp001 from Vibrio …

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WebLysins, also known as endolysins or murein hydrolases, are hydrolytic enzymes produced by bacteriophages in order to cleave the host's cell wall during the final stage of the lytic … WebJun 3, 2024 · Developing chimeric lysins with a wide lytic spectrum is important in fighting against Gram-negative pathogenic bacteria. In the present work, a novel chimerical lysin, LytAmfi, was constructed by fusing the bacteriophage endolysin Lyt μ1/6 with an amphipathic cationic peptide derived from T4 lysozyme. The result showed that the …

WebFeb 10, 2024 · The control was performed without chimeric lysin. (A) Changes in total viable counts in the chilled chicken during storage at 4 °C for 14 days. (B) Changes in the pH of the chilled chicken during ... WebLysine is an essential amino acid.The human body cannot make lysine, so it must be eaten in the diet. Sources include meat, fish, dairy, and eggs. Lysine is a building block for …

WebAug 24, 2024 · Lysine is an herbal supplement used for athletic performance enhancement, or treatment for cold sores (herpes simplex libialis) and elevated pH (metabolic … WebMay 25, 2024 · Rhizobial lipochitooligosaccharidic Nod factors (NFs), specified by nod genes, are the primary determinants of host specificity in the legume–Rhizobia symbiosis.; We examined the nodulation ability of Medicago truncatula cv Jemalong A17 and M. truncatula ssp. tricycla R108 with the Sinorhizobium meliloti nodF/nodL mutant, which …

WebLysin definition, an antibody causing the disintegration of erythrocytes or bacterial cells. See more.

WebApr 15, 2024 · Previously, we reported a broad-spectrum chimeric lysin, ClyR, with a cysteine, histidine-dependent amidohydrolase/peptidase catalytic domain from PlyC lysin and an SH-3b cell-wall binding domain from PlySs2 lysin. Herein, we further report that a novel internal cell-penetrating peptide (CPP) is predicted in the junction region of the two ... derric harsh jr chry 3412046WebJan 9, 2024 · Yang, H. et al. Novel chimeric lysin with high-level antimicrobial activity against methicillin-resistant Staphylococcus aureus in vitro and in vivo. Antimicrob. Agents Chemother. 58 , 536–542 ... c hr xle reviewWebJan 9, 2024 · Developing chimeric lysins (chimeolysins) by shuffling these two domains from different natural lysins has been demonstrated to be a … derric johnson you\\u0027ll never walk aloneWebJan 9, 2024 · A novel chimeric lysin with robust antibacterial activity against planktonic and biofilm methicillin-resistant Staphylococcus aureus Methicillin-resistant Staphylococcus … chry aimoneWebMar 29, 2024 · Chimeric lysin candidates were created through fusion with various enzymatic and cell-wall-binding domains based on LysK lysin, autolysins and lysostaphin … chry 200 2013WebIn this study, we evaluated the anti-biofilm and anti-demineralization abilities of a novel material, CMC-ClyR-ACP nanogel, designed by loading the chimeric lysin ClyR and amorphous calcium phosphate (ACP) into a nanocarrier material carboxymethyl chitosan (CMC), in a demineralization model. chry 300