Nettet2. okt. 2024 · Secondly, vancomycin is associated with renal toxicity and neutropenia 51. Thirdly, protein synthesis inhibition by linezolid produces a ‘non-bacteriolytic’ action and reduces virulence factor ... Nettet24. des. 2024 · Objectives To summarize the pharmacokinetics of linezolid to optimize the dosing regimen in special populations. Methods A literature search was performed in three largest medical databases, including Embase, Scopus, and PubMed. The main applied keywords were linezolid and pharmacokinetics. Of 3663 retrieved publications in the …
Linezolid-Associated Acute Interstitial Nephritis and Drug Rash …
Nettet14. jun. 2024 · Despite reported renal CL of linezolid of about 30%, the impact of renal function could be more than expected a priori. ... Fang J, Zhang X-S, Zhang C-H, Zhou Z-Y, Han L, Wang Y-X, et al. Model based identification of linezolid exposure–toxicity thresholds in hospitalized patients. Front Pharmacol. 2024;12:2390. Nettet5. des. 2016 · Recent studies have reported that the incidence of linezolid-induced thrombocytopenia was higher in patients with renal failure than in patients with normal renal function, although no underlying mechanism has been proposed for the thrombocytopenia. 32,33 The effect of renal insufficiency on erythrocyte and platelet … 14醇
Lactic acidosis associated with standard dose linezolid in a kidney …
Nettet1. jan. 2024 · Abstract. Severe lactic acidosis, a mitochondrial toxicity caused by the recommended standard dosage of linezolid (LZD), may occur in patients with impaired … Nettet4. mai 2024 · This demonstrates that the implication of renal function in the toxicity of linezolid is still poorly known. Other risk factors have been described in the literature, which were not highlighted in our study, like a low body weight [ 17 , 18 ], a low basal platelet count [ 18 , 25 ], or an older age [ 17 ]. 14開口板手