WebAug 21, 2024 · After a 24-h stimulation, the total RNA was extracted, and RT-PCR was applied to identify the M2 macrophage markers (IL-10, TGF-β, and CD206). The results showed that the expression of IL-10, TGF-β, and CD206 increased along with the increased concentration of IL-6 (Fig. 2 a–c). WebIL-10 is an anti-inflammatory cytokine with a strong capacity to suppress proinflammation [14, 57]. In animal models, IL-10 is significantly increased in the serum within 6 h after myocardial ischemia/reperfusion [14]. In a variety of cell types, IL-10 inhibits the release of proinflammatory mediators [4, 38, 41].
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WebIL-10 knockdown completely abolished the effect of TNA on microglial M2 polarization. Conclusion: Taken together, our data demonstrated that TNA attenuates neuronal loss in mouse TBI model and promotes M2 microglia by ERβ/IL-10 pathway. Thus, TNA could be a potential drug for TBI and/or the disorders that caused by microglial over-activation ... WebSep 28, 2016 · IL-10, VEGF-A, VEGF-C and MMP-1 were markedly secreted by M2 macrophage induced from THP-1 as compared with THP-1 cells. (A-D) correlation was analyzed using Pearson Correlation analysis method ... happy birthday davey images
IL-4/IL-13 polarization of macrophages enhances Ebola virus ...
WebJul 21, 2024 · Functional characterization of M1 and M2 macrophages. a Generally, M1 is tumor-resistant by directly lysing tumor cells after phagocytosis, and pro-inflammatory by enhanced tumor antigen-presenting ability or by indirectly promote the proliferation of immune cells like CD8 + T cells and NK cells (due to the effect of IL-6, IL-12 and TNF, et … WebThe IL-2 M-82 is a premium gift rank II Soviet strike aircraft with a battle rating of 2.7 (AB/RB/SB). It was introduced during Update "Starfighters" as a reward for World War … WebJan 20, 2015 · M2 microglia include the states of both alternative activation and acquired deactivation, which are induced by IL-4/IL-13 and IL-10/TGF-β, respectively. M2 microglia facilitate phagocytosis of cell debris and misfolded proteins, promote ECM reconstruction and tissue repair, and support neuron survival by neurotrophic factors. chairmanning