Paclitaxel resistance mechanism
WebPaclitaxel Resistance: Molecular Mechanisms and Pharmacologic Manipulation Bentham Science It has been approximately ten years since the Food and Drug Administration (FDA) approved paclitaxel for the treatment of platinum resistant epithelial ova newsletter banner Search anything here Login Login Remember Me Login WebApr 9, 2024 · Two principal mechanisms of resistance have been described for this drug. Some tumors are known to contain tubulin subunits with a reduced ability to polymerize …
Paclitaxel resistance mechanism
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WebJan 1, 2024 · This study aims to verify the role and the underlying mechanisms of CD147 in paclitaxel resistance. Immunostaining was used to analyze human non-small-cell lung cancer (NSCLC) and ovarian... WebDec 14, 2024 · PTX resistance pathways that involve major regulatory proteins/RNAs like RNF8/Twist/ROR1, TLR, ErbB3/ErbB2, BRCA1- IRIS, MENA, LIN9, MiRNA, FoxM1 and IRAK1 have expanded the complexity of resistance mechanisms, and brought newer insights into the development of drug targets.
WebAs a first-line chemotherapeutic agent for a variety of tumors, it can inhibit the depolymerization of tubulin to block the mitosis of tumor cells and ultimately induce apoptosis of tumor cells and eventually induce the apoptosis of tumor cells. 5,6 Whereas, paclitaxel displayed no obvious effect on HCC, and its drug resistance mechanism also ... WebChemotherapy resistance is a huge barrier for head and neck cancer (HNC) patients and therefore requires close attention to understand its underlay mechanisms for effective strategies. In this review, we first summarize the molecular mechanisms of chemotherapy resistance that occur during the treatment with cisplatin, 5-fluorouracil, and …
WebDec 14, 2024 · Paclitaxel (PTX) is heavily relied on as a frontline chemotherapy drug in breast cancer treatment, especially in advanced metastatic cancer. Generation of … WebFeb 20, 2015 · The mechanism of paclitaxel resistance is complex, involving multistep and multiple genes, and not yet fully elucidated. Development of drug resistance, leading to aggressive disease that is refractory to treatment, is responsible for 90% of the deaths among patients with advanced ovarian cancer [ 70 ].
WebOct 21, 2024 · PTX resistance mechanisms are different and involve alterations in α- and β-tubulin, increased expression and activity of multidrug resistance (MDR) efflux transporters, overexpression of anti-apoptotic proteins, inhibition of apoptotic and tumor-suppressor proteins, and modulation of several cytokines, chemokines, and transcription …
WebPaclitaxel-Resistant Cell Line For example, a paclitaxel resistant cell line with a mutation in tubulin required less vinblastine than wild-type cells to accumulate microtubule fragments whereas a colcemid resistant tubulin mutant required more vinblastine [78]. From: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2011 Tubulin Taxoid ekaterina nechayeva atomic heartWebAug 23, 2024 · We aimed to explore the drug resistance reversal mechanism of the octreotide-paclitaxel conjugate at the molecular level, to confirm the improvement in the response of ovarian cancer cells to paclitaxel, so as to increase the overall survival rate of recurrent ovarian cancer patients and improve the prognosis. ... The human ovarian … food attendancefood attendant qualificationsWebFeb 16, 2024 · To explore the mechanism of paclitaxel resistance in lung adenocarcinoma A549 cells, an A549-T cell model was established by increasing the drug concentration in vitro. Single-cell-derived clones of A549 and A549-T cell lines were obtained by a limited dilution strategy, and were used for further study. food at tampines hubWebThe Major Mechanisms of Paclitaxel Resistance. The cellular mechanism of action by which paclitaxel serves as an anticancer drug, as illustrated following the black arrows. Paclitaxel... ekaterina roman of iowaWebAug 9, 2016 · Results: Paclitaxel-resistant cells were cross-resistant to olaparib, doxorubicin and rucaparib but not to veliparib or AZD2461. Resistance correlated with increased ABCB1 expression and was reversible following treatment with the ABCB1 inhibitors verapamil and elacridar. ekaterina savvy magdie foot comparisonWebThe Major Mechanisms of Paclitaxel Resistance. The cellular mechanism of action by which paclitaxel serves as an anticancer drug, as illustrated following the black arrows. … food at teban garden